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SORTILIN IS A NOVEL TARGET WITHIN NEUROPSYCHIATRIC AND NEURODEGENERATIVE DISEASES. SORTILIN PLAYS A VITAL ROLE IN KEEPING NEURONAL INTEGRITY AND NEUROPLASTICITY. VESPER BIO IS DEVELOPING SELECTIVE SORTILIN INHIBITORS FOR NEUROLOGICAL DISEASES WITH HIGH UNMET NEED.
SORTILIN
OUR SCIENTIFIC FOUNDERS PIONEERED UNDERSTANDING OF THE ROLE OF THIS MULTIFUNCTIONAL PROTEIN EXPRESSED IN NEURONS AND MICROGLIA. IT BINDS MULTIPLE LIGANDS, INCLUDING PROGRANULIN, PRONEUROTROPHINS, AND NEUROTENSIN AND REGULATES THEIR TRAFFICKING AND DEGRADATION.
VESPER BIO TARGETS SORTILIN USING ORAL SMALL MOLECULES. THIS APPROACH SELECTIVELY MODULATE LIGAND BINDING TO SORTILIN WITH THE POTENTIAL TO IMPROVE NEUROINFLAMMATION, REDUCE APOPTOSIS AND IMPROVE LYSOSOMAL FUNCTION.
WE KNOW SORTILIN
OUR SCIENTIFIC ADVISORS
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