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FTD-GRN IS A GENETICALLY DEFINED DISEASE CHARACTERISED BY REDUCED LEVELS OF PROGRANULIN LEADING TO NEURODEGENERATION, NEUROINFLAMMATION AND DEATH. VES001 NORMALISES PROGRANULIN LEVELS BY INTERRUPTING ITS BINDING TO THE MULTIFUNCTIONAL PROTEIN SORTILIN. SORTILIN INHIBITORS ARE BEING INVESTIGATED FOR MUCH MORE THAN NORMALISING PROGRANULIN LEVELS, AND WE HAVE PROGRAMS IN PARKINSON’S DISEASE AND RETINAL NEUROPATHIES.

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DISCOVER OUR INNOVATIVE APPROACH TO TACKLING FTD, WITH A FOCUS ON FTD-GRN

20221115 vesperBio-06 (with music)
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SORTILIN

OUR SCIENTIFIC FOUNDERS HAVE PIONEERED THE UNDERSTANDING THE ROLE OF THIS MULTIFUNCTIONAL PROTEIN EXPRESSED IN NEURONS AND MICROGLIA. IT BINDS MULTIPLE LIGANDS, INCLUDING PROGRANULIN, PRONEUROTROPHINS, NEUROTENSIN, AND APOB, AND REGULATES THEIR TRAFFICKING AND DEGRADATION.

 

VESPER BIO TARGETS SORTILIN AT THE CELL SURFACE USING ORAL SMALL MOLECULES AND ANTIBODIES. THIS APPROACH SELECTIVELY DISRUPTS SORTILIN’S PATHOLOGICAL INTERACTION WITH PROGRANULIN, SAFELY RESTORING PROGRANULIN LEVELS WITH THE POTENTIAL TO IMPROVE NEUROINFLAMMATION, REDUCE APOPTOSIS AND IMPROVE LYSOSOMAL FUNCTION.

WE KNOW SORTILIN

REVERSIBLE INHIBITION OF SORTILIN

VESPER BIO HAS GENERATED NOVEL, POTENT, ORALLY AVAILABLE SMALL MOLECULES THAT TARGET SORTILIN AT THE CELL MEMBRANE AND SPECIFICALLY INTERRUPT KEY PROTEIN-PROTEIN INTERACTIONS. WE DO NOT INTERFERE WITH SORTILIN’S INTRACELLULAR ROLE IN PROTEIN TRAFFICKING.

OUR SCIENTIFIC ADVISORS

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